Wednesday, May 14, 2008

Triple Negative

Triple negative means the tumor is ER- (estrogen receptor negative), PR- (progesterone receptor negative) and HER2- (HER2/neu negative). If you're ER- and PR-, you can't be treated with tamoxifen (for premenopausal women) nor aromatase inhibitors (for post-menopausal women), two types of hormonal therapy. If you're HER2-, you can't be treated with Herceptin, a biological therapy. Triple negative cancers are very aggressive and typically found in younger women.

Triple negative also means you could have the BRCA1 gene mutation. I need to follow up on this.

No comments: